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Top Alpha 1 Anti Trypsin Deficiency treatment by Dr. Bharat Pothuri

Alpha 1 Antitrypsin Deficiency (AATD) is a genetically determined disease, which leads to the progressive destruction of the lung and liver as a result of lack of protective A1AT protein. The Dr. Bharat Pothuri at GastroDoxs Houston offers an extensive evidence based diagnostics, individualized treatments and sophisticated therapies according to each patient needs.

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Difficulty Swallowing

American Society for Gastrointestinal Endoscopy

About the Expert

Dr. Bharat Pothuri is a board-certified gastroenterologist and the founder of GastroDoxs. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

Common Causes and Risk Factors

Hereditary mutations of SERPINA1 gene.
Lung/liver disease in the family.
Smoking of cigarettes, which hastens the destruction of the lung.
Age (the symptoms usually start at 30-50 years)
Northern European (greater carrier rate) ancestry.

Signs and Symptoms

Frequently, little or nonexistent in early stages.
Dyspnea or wheezing with exercise.
Persistent cough or recurrent illness of lungs or respiratory tract attacks.
Constant fatigue or a low exercise capacity.
Jaundice of the skin or eyes (yellowing)
Liver disease: Swelling of legs, abdomen in the progressive disease.

Alpha 1 Anti Trypsin Deficiency and Expert Treatment with Dr. Bharat Pothuri.

Step 1: Historical and physical examination.

The family and health history of the patient are discussed by Dr. Pothuri. He hears your lungs and searches your liver enlarging.

Step 2: Group Test of A1AT Levels.

Blood draw is performed to analyze A1AT (Alpha-1 Antitrypsin) level of protein.

Step 3: Genetic Testing

In case of low levels of A1AT, mutations in SERPINA1 gene are verified by the means of a DNA test.

Step 4: Lung Function Tests and Imaging.

The damage of lungs is evaluated by chest X-rays, CT-scans, and spirometry. Liver ultrasound/FibroScan is used to screen liver disease.

Treatment

We have a multispecialty team, which deals in complete care of Alpha 1 Antitrypsin Deficiency.

1. Lifestyle and Diet Tips

Stop smoking - slows down pulmonary damage.
Low fat, high in fruits and vegetable dietary plan.
Frequent workout protocol to keep muscles and the lungs strong.
Modern influenza and pneumonia vaccinations to avoid infections.

2. Medications

Augmentation treatment - IV to enhance levels with A1AT protein.
Inhalers and corticosteroids - make the breathing easy and less inflamed.
Letal support drugs - control liver symptoms.

3. Minimal Invasive and High tech Operations.

Endoscopic lung volume reduction - done to clear up pitted lung tissue.
Placement of bronchoscopic valves - diverts airflow to other easier-to-breath lung areas.
Liver transplant - when the liver becomes end-stage.

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1.5K

Patients Treated

Dr. Pothuri has treated more than 1.5K patients, helping individuals improve their digestive health and overall well-being through expert, personalized care.

20Y

Years of Experience

With over 20 years of experience, GastroDoxs has been a trusted provider of gastroenterology care, focusing on delivering the best outcomes for patients

About the Author

Dr. Bharat Pothuri is a Board-Certified Gastroenterologist and Hepatologist. With extensive experience in digestive health, he specializes in advanced endoscopic procedures, chronic GI disorder management, and preventive care. Dr. Pothuri is dedicated to providing expert, patient-focused insights to help improve gut health and overall well-being.

Frequently Asked Questions

How many years can you live with AATD?

It varies by individual. By the early diagnosis and smoking cessation combined with proper treatments, the long-term results may be greatly improved.

Does genetic test identify AATD in children or newborns?

Yes. Any form of genetic testing is able to recognize variants of AATD in people of any age, such as screening in newborn and testing in asymptomatic relatives.

Is there reversible liver damage related to AATD?

Light to moderate liver damage can be stabilized or cured through treatment and lifestyle modification. Severe cirrhosis can be transplantated.

Is there any clinical trial or novel treatment of AATD?

Yes. Some clinics and research centers in Houston are testing new types of augmentation therapies, gene editing, and also small-molecule drugs.

Is the augmentation therapy covered by Medicare?

The A1AT augmentation infusions have at least partial coverage under most Medicare and other private plans. Our billing department aids in checking of benefits.

What can I do in preparation of my initial visit?

With you: any previous testing (blood tests, radiographs) records, a list of your current drugs, and information about your family history of lung or liver disease.

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